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Published Articles Found

2017

  Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain
Grimley E, et al., ACS Chem Biol, 12(3):724-734, 2017

2015

  Design, Synthesis, and Structure-Activity Relationship of Novel LSD1 Inhibitors Based on Pyrimidine-Thiourea Hybrids as Potent, Orally Active Antitumor Agents
Ma L, et al., J Med Chem, 58(4):1705-16., 2015

  Functional Label-Free Assays for Characterizing the In Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly
Lad L, et al., Biochemistry, 54(13):2240-8, 2015

  3, 4-dihydroxyl-phenyl Lactic Acid Restores NADH Dehydrogenase 1 α Subunit 10 to Ameliorate Cardiac Reperfusion Injury
Yang X, et al., Sci Rep, 5:10739, 2015

  A Novel Synthetic Small Molecule YH-306 Suppresses Colorectal Tumour Growth and Metastasis Via FAK Pathway
Dai F, et al., J Cell Mol Med, 19(2):383-95, 2015

  Anticancer Activity of a Novel Selective CYP17A1 Inhibitor in Preclinical Models of Castrate-Resistant Prostate Cancer
Toren P, et al., Mol Cancer Ther, 14(1):59-69, 2015

  Modulation of the Binding of Basic Fibroblast Growth Factor and Heparanase Activity by Purified λ-Carrageenan Oligosaccharides
Niu T, eta;., Carbohydr Polym, 125:76-84, 2015

  Label-Free Detection of Small-Molecule Binding to a GPCR in the Membrane Environment
Heym R, et al., Biochim Biophys Acta, 1854(8):979-86, 2015

2014

  Validation of Aspergillus Fumigatus Glucosamine-6-phosphate N-acetyltransferase as a Potential Antifungal Target
Lockhart D, et al., The Lancet, 383:S69, 2014

  Selectively Targeting the DNA Binding Domain of the Androgen Receptor as a Prospective Therapy for Prostate Cancer
Dalal K, et al., J Biol Chem, pii: jbc.M114.553818, 2014

  Semi-continuous, Label-free Immunosensing Approach for Ca2+-based Conformation Change of a Calcium Binding Protein
Paek SH, et al., Analyst, 139(15):3781-9, 2014

  Discovery of Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis
Jiang ZY, et al., J Med Chem, 57(6):2736-45, 2014

  The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) is Druggable
Benod C, et al., PLoS One, 9(6):e99440, 2014

  Structural and Functional Analysis of G Protein-coupled Receptor Kinase Inhibition by Paroxetine and a Rationally Designed Analog
Homan KT, et al., Mol Pharmacol, 85, 237-248, 2014

  Bisubstrate UDP-peptide Conjugates as Human O-GlcNAc Transferase Inhibitors
Borodkin VS, et al., Biochem J, 457, 497-502, 2014

2013

  A Protein Engineering of Bacillus Thuringiensis δ-Endotoxin by Conjugating with 4"-O-succinoyl Abamectin
Pan Z, et al., Int J Biol Macromol, 62, 211-6, 2013

  Small-molecule Modulation of Wnt Signaling via Modulating the Axin-LRP5/6 Interaction
Wang S, et al., Nat Chem Biol, 9(9), 579-85, 2013

  Disruption of Focal Adhesion Kinase and p53 Interaction with Small Molecule Compound R2 Reactivated p53 and Blocked Tumor Growth
Golubovskaya V, et al., BMC Cancer, 13(1), 342, 2013

  Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels
Miyata, Y, et al., ACS Chem Neurosci, 4(6), 930-939, 2013

  Targeting the Binding Function 3 (BF3) Site of the Androgen Receptor Through Virtual Screening. 2. Development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole Derivatives
Munuganti, R S, et al., J Med Chem, 56(3), 1136-48, 2013

  Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood-Brain Barrier
Bachmeier, C, et al., J Mol Neurosci, 49(2), 270-6, 2013

  Switchable Elastin-like Polypeptides that Respond to Chemical Inducers of Dimerization
Dhandhukia, J, et. al., Biomacromolecules, 14(4), 976-85 , 2013

  An Evaluation of the Capability of a Biolayer Interferometry Biosensor to Detect Low-molecular-weight Food Contaminants
McGrath, T F, et al., Anal Bioanal Chem, 405(8), 2535-44, 2013

2012

  Metformin Interacts with AMPK Through Binding to γ Subunit
Zhang, Y., et al., Mol Cell Biochem, 368(1-2), 69-76, 2012

  1-(2,6-Dibenzyloxybenzoyl)-3-(9H-fluoren-9-yl)-urea: A Novel Cyclophilin A Allosteric Activator
M. Lv, et al. , Biochem Biophys Res Commun, 425(4), 938-943, 2012

  Bacillus anthracis Inosine 5'-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes
M. Makowska-Grzyska, et al. , Biochemistry, 51(31), 6148-6163, 2012

2011

  Formation of Raloxifene Homo-dimer in CYP3A4, Evidence for Multi-substrate Binding in a Single Catalytically Competent P450 Active Site
Davis, J.A., et al., Arch Biochem Biophys, 513(2), 110-118, 2011

  Novartis Evaluation of the ForteBio Octet RED: A Versatile Instrument for Direct Binding Experiments
Cooper, M., et al., Label-Free Technologies for Drug Discovery, Ch 15, Feb 24 Epub, 2011

  Biosensor-based Small Molecule Fragment Screening with Biolayer Interferometry
Wartchow, C.A., et al., J Comput Aided Mol Des, 25(7), 669-676, 2011

2010

  Cytokine Binding by Polysaccharide-Antibody Conjugates
Sun, L.T., et al., Molecular Pharmaceutics, 7(5), 1769-1777, 2010

  Gambogic Acid Inhibits Hsp90 and Deregulates TNF-alpha/NF-kappaB in HeLa Cells
Zhang, L., et al., Biochem Biophys Res Commun, 403(3-4), 282-287, 2010

Documents Found

Biosensor-based Fragment Screening and Hit Confirmation with Protein-protein Interaction (PPI) Targets

  Biosensor-based Fragment Screening and Hit Confirmation with Protein-protein Interaction (PPI) Targets

Ligand Affinity Measurements for the Community Structure Activity Resource Center(CSAR)

  Ligand Affinity Measurements for the Community Structure Activity Resource Center(CSAR)

Hit Identification and Lead Confirmation in the Discovery of Drugs Targeting Bromodomain Proteins

  Hit Identification and Lead Confirmation in the Discovery of Drugs Targeting Bromodomain Proteins

Hit Identification and Lead Confirmation in the Drug Discovery of Bromodomain Proteins

  Hit Identification and Lead Confirmation in the Drug Discovery of Bromodomain Proteins

Hit Identification and Lead Confirmation in the Drug Discovery of Bromodomain Proteins

  Hit Identification and Lead Confirmation in the Drug Discovery of Bromodomain Proteins

Hit Identification and Lead Confirmation in the Drug Discovery of Bromodomain Proteins

  Hit Identification and Lead Confirmation in the Drug Discovery of Bromodomain Proteins

AN 8: Optimizing Protein-Protein and Protein-Small Molecule Kinetics Assays

  AN 8: Optimizing Protein-Protein and Protein-Small Molecule Kinetics Assays

AN 7: Generating Reliable Kinetic Data for Protein-Ligand Interaction

  AN 7: Generating Reliable Kinetic Data for Protein-Ligand Interaction

AN 6: Reducing Variability in Small Molecule Screening and Kinetics Applications

  AN 6: Reducing Variability in Small Molecule Screening and Kinetics Applications

Using Octet RED384 for Higher Throughput Screening of Small Molecules and Fragments

  Using Octet RED384 for Higher Throughput Screening of Small Molecules and Fragments

Fragment Library Screening Using the ForteBio Octet RED

  Fragment Library Screening Using the ForteBio Octet RED

ForteBio Octet RED - A Label-free Instrument that Provides Binding Data in a Simplified, No Flow, Dip and Read Configuration

  ForteBio Octet RED - A Label-free Instrument that Provides Binding Data in a Simplified, No Flow, Dip and Read Configuration